ParkinsonFranceV1, Main, Exploration, bibRecord, 003543

Association between the extended tau haplotype and frontotemporal dementia

Identifieur interne : 003543 ( Main/Exploration ); précédent : 003542; suivant : 003544

Association between the extended tau haplotype and frontotemporal dementia

Auteurs : Patrice Verpillat [France] ; Agnès Camuzat [France] ; Didier Hannequin [France] ; Catherine Thomas-Anterion [France] ; Michèle Puel [France] ; Serge Belliard [France] ; Bruno Dubois [France] ; Mira Didic [France] ; Bernard-Francois Michel [France] ; Lucette Lacomblez [France] ; Olivier Moreaud [France] ; Francois Sellal [France] ; Véronique Golfier [France] ; Dominique Campion [France] ; Francoise Clerget-Darpoux [France] ; Alexis Brice [France]

Source :

Archives of neurology : (Chicago) [ 0003-9942 ] ; 2002.

RBID : Pascal:02-0389825

Descripteurs français

Pascal (Inist)
- Démence, Lobe frontal, Lobe temporal, Haplotype, Protéine tau, Facteur risque, Etiopathogénie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Case-Control Studies, Confidence Intervals, Dementia, Dementia (genetics), Etiopathogenesis, Female, Frontal lobe, Genotype, Haplotype, Haplotypes (genetics), Human, Humans, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk factor, Tau protein, Temporal lobe, tau Proteins (genetics).
MESH :
- chemical , genetics : tau Proteins.
- genetics : Dementia, Haplotypes.
- Adult, Aged, Case-Control Studies, Confidence Intervals, Female, Genotype, Humans, Male, Middle Aged, Multivariate Analysis, Odds Ratio.

Abstract

Background: Recent studies have shown an association between an extended tau haplotype (H1) that covers the entire human tau gene and progressive supranuclear palsy or, more inconsistently, other neurodegenerative disorders, such as corticobasal degeneration, Parkinson disease, Alzheimer disease, and frontotemporal dementia (FTD). In addition, disease-causing mutations in the tau gene on chromosome 17 have been detected in some families with autosomal dominant FTD and parkinsonism. In FTD, the pathological accumulation of the microtubule-associated protein tau suggests that the tau gene may be a genetic risk factor for this disorder. Objective: To confirm or refute the association between the H1 haplotype or the H1H1 genotype of the tau gene and FTD. Design: Case-control study. Setting: Neurology departments of 12 French university hospitals. Participants: One hundred unrelated patients with FTD and 79 controls. Methods: Tau genotype (contiguous polymorphisms in exons 1, 7, and 13 and in intron 9 used to reconstruct the extended haplotypes H1 and H2). Clinical examination, psychometric testing, laboratory tests, computed tomography and magnetic resonance imaging, single-photon emission computed tomography, and electroencephalography for patients with FTD. Results: The H1H1 genotype was significantly overrepresented in patients with FTD compared with controls (62% vs 46%; P=.01, 1-sided; odds ratio adjusted for age and sex, 1.95). After stratification according to apolipoprotein E (APOE) genotype, we found a significant interaction between APOE and tau genotypes (P=.03). Conclusions: This study of the largest series of patients with FTD confirms the primary role of tau in FTD and establishes that the H 1 haplotype of the tau gene and the E2 allele of APOE interact by an unknown mechanism that increases the risk of FTD.

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Association between the extended tau haplotype and frontotemporal dementia</title>
<author><name sortKey="Verpillat, Patrice" sort="Verpillat, Patrice" uniqKey="Verpillat P" first="Patrice" last="Verpillat">Patrice Verpillat</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Epidemiology and Biostatistics, University Hospital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris (AP-HP)/ University Paris VII</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U289, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Camuzat, Agnes" sort="Camuzat, Agnes" uniqKey="Camuzat A" first="Agnès" last="Camuzat">Agnès Camuzat</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U289, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM Equipe Propre Inserm (EPI) 9906</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Hospital</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas Anterion, Catherine" sort="Thomas Anterion, Catherine" uniqKey="Thomas Anterion C" first="Catherine" last="Thomas-Anterion">Catherine Thomas-Anterion</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurology, University Hospital</s1>
<s2>Saint-Etienne</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Saint-Étienne</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puel, Michele" sort="Puel, Michele" uniqKey="Puel M" first="Michèle" last="Puel">Michèle Puel</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, University Hospital Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belliard, Serge" sort="Belliard, Serge" uniqKey="Belliard S" first="Serge" last="Belliard">Serge Belliard</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neurology, University Hospital Pontchaillou</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Didic, Mira" sort="Didic, Mira" uniqKey="Didic M" first="Mira" last="Didic">Mira Didic</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Neurology and Neuropsychology, University Hospital Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>INSERM Equipe Mixte Inserm (EMI) U9926</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michel, Bernard Francois" sort="Michel, Bernard Francois" uniqKey="Michel B" first="Bernard-Francois" last="Michel">Bernard-Francois Michel</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Neurology, University Hospital Sainte-Marguerite</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Federation of Neurology Mazarin and the Department of Pharmacology, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreaud, Olivier" sort="Moreaud, Olivier" uniqKey="Moreaud O" first="Olivier" last="Moreaud">Olivier Moreaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Neurology, University Hospital</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sellal, Francois" sort="Sellal, Francois" uniqKey="Sellal F" first="Francois" last="Sellal">Francois Sellal</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Neurology, University Hospital</s1>
<s2>Strasbourg</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Golfier, Veronique" sort="Golfier, Veronique" uniqKey="Golfier V" first="Véronique" last="Golfier">Véronique Golfier</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neurology, University Hospital Pontchaillou</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM Equipe Propre Inserm (EPI) 9906</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clerget Darpoux, Francoise" sort="Clerget Darpoux, Francoise" uniqKey="Clerget Darpoux F" first="Francoise" last="Clerget-Darpoux">Francoise Clerget-Darpoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U289, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Genetics, Cytogenetics and Embryology, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">02-0389825</idno>
<date when="2002">2002</date>
<idno type="stanalyst">PASCAL 02-0389825 INIST</idno>
<idno type="RBID">Pascal:02-0389825</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001076</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000360</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000F71</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000F71</idno>
<idno type="wicri:doubleKey">0003-9942:2002:Verpillat P:association:between:the</idno>
<idno type="wicri:Area/Main/Merge">003A86</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:12056929</idno>
<idno type="wicri:Area/PubMed/Corpus">001184</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001184</idno>
<idno type="wicri:Area/PubMed/Curation">001143</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001143</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001143</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001143</idno>
<idno type="wicri:Area/Ncbi/Merge">000251</idno>
<idno type="wicri:Area/Ncbi/Curation">000251</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000251</idno>
<idno type="wicri:doubleKey">0003-9942:2002:Verpillat P:association:between:the</idno>
<idno type="wicri:Area/Main/Merge">003855</idno>
<idno type="wicri:Area/Main/Curation">003543</idno>
<idno type="wicri:Area/Main/Exploration">003543</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Association between the extended tau haplotype and frontotemporal dementia</title>
<author><name sortKey="Verpillat, Patrice" sort="Verpillat, Patrice" uniqKey="Verpillat P" first="Patrice" last="Verpillat">Patrice Verpillat</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Epidemiology and Biostatistics, University Hospital Bichat-Claude Bernard, Assistance Publique-Hôpitaux de Paris (AP-HP)/ University Paris VII</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U289, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Camuzat, Agnes" sort="Camuzat, Agnes" uniqKey="Camuzat A" first="Agnès" last="Camuzat">Agnès Camuzat</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U289, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM Equipe Propre Inserm (EPI) 9906</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Department of Neurology, University Hospital</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomas Anterion, Catherine" sort="Thomas Anterion, Catherine" uniqKey="Thomas Anterion C" first="Catherine" last="Thomas-Anterion">Catherine Thomas-Anterion</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurology, University Hospital</s1>
<s2>Saint-Etienne</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Saint-Étienne</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Puel, Michele" sort="Puel, Michele" uniqKey="Puel M" first="Michèle" last="Puel">Michèle Puel</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neurology, University Hospital Purpan</s1>
<s2>Toulouse</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Occitanie (région administrative)</region>
<region type="old region">Midi-Pyrénées</region>
<settlement type="city">Toulouse</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belliard, Serge" sort="Belliard, Serge" uniqKey="Belliard S" first="Serge" last="Belliard">Serge Belliard</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neurology, University Hospital Pontchaillou</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Department of Neurology, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Didic, Mira" sort="Didic, Mira" uniqKey="Didic M" first="Mira" last="Didic">Mira Didic</name>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Department of Neurology and Neuropsychology, University Hospital Timone</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>INSERM Equipe Mixte Inserm (EMI) U9926</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Michel, Bernard Francois" sort="Michel, Bernard Francois" uniqKey="Michel B" first="Bernard-Francois" last="Michel">Bernard-Francois Michel</name>
<affiliation wicri:level="3"><inist:fA14 i1="12"><s1>Department of Neurology, University Hospital Sainte-Marguerite</s1>
<s2>Marseille</s2>
<s3>FRA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Federation of Neurology Mazarin and the Department of Pharmacology, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moreaud, Olivier" sort="Moreaud, Olivier" uniqKey="Moreaud O" first="Olivier" last="Moreaud">Olivier Moreaud</name>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Neurology, University Hospital</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Grenoble</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sellal, Francois" sort="Sellal, Francois" uniqKey="Sellal F" first="Francois" last="Sellal">Francois Sellal</name>
<affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Department of Neurology, University Hospital</s1>
<s2>Strasbourg</s2>
<s3>FRA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Grand Est</region>
<region type="old region">Alsace (région administrative)</region>
<settlement type="city">Strasbourg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Golfier, Veronique" sort="Golfier, Veronique" uniqKey="Golfier V" first="Véronique" last="Golfier">Véronique Golfier</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Department of Neurology, University Hospital Pontchaillou</s1>
<s2>Rennes</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Bretagne</region>
<region type="old region">Région Bretagne</region>
<settlement type="city">Rennes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>INSERM Equipe Propre Inserm (EPI) 9906</s1>
<s2>Rouen</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Région Normandie</region>
<region type="old region">Haute-Normandie</region>
<settlement type="city">Rouen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Clerget Darpoux, Francoise" sort="Clerget Darpoux, Francoise" uniqKey="Clerget Darpoux F" first="Francoise" last="Clerget-Darpoux">Francoise Clerget-Darpoux</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</s1>
<s2>Le Kremlin Bicêtre</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Le Kremlin Bicêtre</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
<wicri:noRegion>Institut National de la Santé et de la Recherche Médicale (INSERM) U535</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>INSERM U289, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="16"><s1>Department of Genetics, Cytogenetics and Embryology, University Hospital Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Archives of neurology : (Chicago)</title>
<title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title>
<idno type="ISSN">0003-9942</idno>
<imprint><date when="2002">2002</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Archives of neurology : (Chicago)</title>
<title level="j" type="abbreviated">Arch. neurol. : (Chic.)</title>
<idno type="ISSN">0003-9942</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Confidence Intervals</term>
<term>Dementia</term>
<term>Dementia (genetics)</term>
<term>Etiopathogenesis</term>
<term>Female</term>
<term>Frontal lobe</term>
<term>Genotype</term>
<term>Haplotype</term>
<term>Haplotypes (genetics)</term>
<term>Human</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Odds Ratio</term>
<term>Risk factor</term>
<term>Tau protein</term>
<term>Temporal lobe</term>
<term>tau Proteins (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>tau Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Dementia</term>
<term>Haplotypes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Case-Control Studies</term>
<term>Confidence Intervals</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Odds Ratio</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Démence</term>
<term>Lobe frontal</term>
<term>Lobe temporal</term>
<term>Haplotype</term>
<term>Protéine tau</term>
<term>Facteur risque</term>
<term>Etiopathogénie</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background: Recent studies have shown an association between an extended tau haplotype (H1) that covers the entire human tau gene and progressive supranuclear palsy or, more inconsistently, other neurodegenerative disorders, such as corticobasal degeneration, Parkinson disease, Alzheimer disease, and frontotemporal dementia (FTD). In addition, disease-causing mutations in the tau gene on chromosome 17 have been detected in some families with autosomal dominant FTD and parkinsonism. In FTD, the pathological accumulation of the microtubule-associated protein tau suggests that the tau gene may be a genetic risk factor for this disorder. Objective: To confirm or refute the association between the H1 haplotype or the H1H1 genotype of the tau gene and FTD. Design: Case-control study. Setting: Neurology departments of 12 French university hospitals. Participants: One hundred unrelated patients with FTD and 79 controls. Methods: Tau genotype (contiguous polymorphisms in exons 1, 7, and 13 and in intron 9 used to reconstruct the extended haplotypes H1 and H2). Clinical examination, psychometric testing, laboratory tests, computed tomography and magnetic resonance imaging, single-photon emission computed tomography, and electroencephalography for patients with FTD. Results: The H1H1 genotype was significantly overrepresented in patients with FTD compared with controls (62% vs 46%; P=.01, 1-sided; odds ratio adjusted for age and sex, 1.95). After stratification according to apolipoprotein E (APOE) genotype, we found a significant interaction between APOE and tau genotypes (P=.03). Conclusions: This study of the largest series of patients with FTD confirms the primary role of tau in FTD and establishes that the H 1 haplotype of the tau gene and the E2 allele of APOE interact by an unknown mechanism that increases the risk of FTD.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Alsace (région administrative)</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Grand Est</li>
<li>Haute-Normandie</li>
<li>Midi-Pyrénées</li>
<li>Occitanie (région administrative)</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Rhône-Alpes</li>
<li>Région Bretagne</li>
<li>Région Normandie</li>
<li>Île-de-France</li>
</region>
<settlement><li>Grenoble</li>
<li>Marseille</li>
<li>Paris</li>
<li>Rennes</li>
<li>Rouen</li>
<li>Saint-Étienne</li>
<li>Strasbourg</li>
<li>Toulouse</li>
</settlement>
</list>
<tree><country name="France"><noRegion><name sortKey="Verpillat, Patrice" sort="Verpillat, Patrice" uniqKey="Verpillat P" first="Patrice" last="Verpillat">Patrice Verpillat</name>
</noRegion>
<name sortKey="Belliard, Serge" sort="Belliard, Serge" uniqKey="Belliard S" first="Serge" last="Belliard">Serge Belliard</name>
<name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<name sortKey="Campion, Dominique" sort="Campion, Dominique" uniqKey="Campion D" first="Dominique" last="Campion">Dominique Campion</name>
<name sortKey="Camuzat, Agnes" sort="Camuzat, Agnes" uniqKey="Camuzat A" first="Agnès" last="Camuzat">Agnès Camuzat</name>
<name sortKey="Clerget Darpoux, Francoise" sort="Clerget Darpoux, Francoise" uniqKey="Clerget Darpoux F" first="Francoise" last="Clerget-Darpoux">Francoise Clerget-Darpoux</name>
<name sortKey="Didic, Mira" sort="Didic, Mira" uniqKey="Didic M" first="Mira" last="Didic">Mira Didic</name>
<name sortKey="Didic, Mira" sort="Didic, Mira" uniqKey="Didic M" first="Mira" last="Didic">Mira Didic</name>
<name sortKey="Dubois, Bruno" sort="Dubois, Bruno" uniqKey="Dubois B" first="Bruno" last="Dubois">Bruno Dubois</name>
<name sortKey="Golfier, Veronique" sort="Golfier, Veronique" uniqKey="Golfier V" first="Véronique" last="Golfier">Véronique Golfier</name>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<name sortKey="Hannequin, Didier" sort="Hannequin, Didier" uniqKey="Hannequin D" first="Didier" last="Hannequin">Didier Hannequin</name>
<name sortKey="Lacomblez, Lucette" sort="Lacomblez, Lucette" uniqKey="Lacomblez L" first="Lucette" last="Lacomblez">Lucette Lacomblez</name>
<name sortKey="Michel, Bernard Francois" sort="Michel, Bernard Francois" uniqKey="Michel B" first="Bernard-Francois" last="Michel">Bernard-Francois Michel</name>
<name sortKey="Moreaud, Olivier" sort="Moreaud, Olivier" uniqKey="Moreaud O" first="Olivier" last="Moreaud">Olivier Moreaud</name>
<name sortKey="Puel, Michele" sort="Puel, Michele" uniqKey="Puel M" first="Michèle" last="Puel">Michèle Puel</name>
<name sortKey="Sellal, Francois" sort="Sellal, Francois" uniqKey="Sellal F" first="Francois" last="Sellal">Francois Sellal</name>
<name sortKey="Thomas Anterion, Catherine" sort="Thomas Anterion, Catherine" uniqKey="Thomas Anterion C" first="Catherine" last="Thomas-Anterion">Catherine Thomas-Anterion</name>
<name sortKey="Verpillat, Patrice" sort="Verpillat, Patrice" uniqKey="Verpillat P" first="Patrice" last="Verpillat">Patrice Verpillat</name>
<name sortKey="Verpillat, Patrice" sort="Verpillat, Patrice" uniqKey="Verpillat P" first="Patrice" last="Verpillat">Patrice Verpillat</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 003543 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 003543 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:02-0389825
   |texte=   Association between the extended tau haplotype and frontotemporal dementia
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

La maladie de Parkinson en France (serveur d'exploration)

Association between the extended tau haplotype and frontotemporal dementia

Association between the extended tau haplotype and frontotemporal dementia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.